Apparently, the big guy has anxiety issues when the family goes out and crates him. Any suggestions? Is it a matter of getting a better quality crate?
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Are they sure it's anxiety or is he just bored? If it's SA he likely will tear at doors and windows when people leave, trying to go after them. If he just chews up pillows or shoes he's probably bored.
Make sure he's good and tired before leaving. Keep comings and goings low key. Don't give attention at all for anxious behavior. Can he be left uncrated? Many dogs with separation anxiety issues also have issues being "closed in". Desensitize him to leaving. Pick up keys, put on coat. Put keys back down, take coat off, don't leave. Pick up keys, walk out the door, walk back in. Don't give any attention while doing this. Do this for a couple days or so. Work up to going out the door, coming in another door, going out the door, staying out 2 minutes, 3 minutes, etc. Slowly increase the time away. Once he's okay for 45 minutes alone or so, he should be okay for a few hours.
If it's really bad, there are meds that can help including one just for SA in dogs called Clomicalm. It has to be given by a vet though and is kind of pricey for a large dog. The idea is to start the dog on the recommended dose then slowly wean according to the vet while working on the behavior. Hopefully eventually the dog can come of the med entirely.
At one time I had a detailed separation anxiety to-do list, but I think it's on an old, no longer usable computer. :/
This might explain some things better than I can.
Separation Anxiety